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Promethazine (proe meth' a zeen) is a first generation antihistamine that is used widely to treat and prevent nausea and to a lesser extent to treat allergy symptoms and as a mild sedative.

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Relative contraindications include a history of treatment for depression and unstable social circumstances.

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When administered before cesarean section, clinically significant neonatal effects have not been observed, even in the presence of measurable serum drug levels in the newborn (Bylsma-Howell et al, 1983).

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Medication tends to be more readily abusable if it has a rapid onset and short duration of action, is highly potent, and is smokable or easily ingested.

However, patients undergoing long-term naltrexone therapy can become sensitized to opioid drugs, heightening the risk of fatal overdose if opioid use is resumed.

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In what age population is the use of all forms of promethazine contraindicated?

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